MitoPrime: L-Ergothioneine – 10mg
How do we make a coffee that competes with these “mushroom coffees” but won’t taste like mushrooms? Go straight to the source and provide what we believe to be the most beneficial compound of the entire mushroom kingdom: L-ergothioneine!
Sold as MitoPrime by NNB Nutrition, L-ergothioneine is an “amino acid antioxidant” that we believe is truly the antioxidant our industry has been searching for. It’s found primarily in organ meats and certain mushroom species,[10-13] two foods we no longer get enough of — and that’s the exact reason we want to directly supplement it.
Considered a “longevity vitamin” by many
Inhibitory effects of Ergothioneine vs. Glutathione, Histidine, and Vitamin C[13]
In fact, after seeing such promising results, ergothioneine is actually considered a “candidate vitamin” to many researchers,[14,15] who believe it should have official status as a vitamin, since it’s so effective yet cannot be made by the body. The prominent Dr. Ames even calls it a “longevity vitamin”.[16,17]
Reason being, ergothioneine increases cell viability – by as much as 45% – and prevents DNA and mitochondrial DNA damage.[18] Both of these benefits are critical to longevity, as we generally see those with healthier DNA live longer.
An antioxidant that works!
Ergothioneine serves several roles in the system, and we’re already wired for it! But are you getting any in your diet?[19]
Cutting right to the chase, research has demonstrated that ergothioneine outperforms the three most popular antioxidants — glutathione, vitamin C, and coenzyme Q10 — and is anywhere from 3-30x more effective when it comes to scavenging free radicals![13,20,21]
For this reason, we believe that this ingredient solves “the antioxidant paradox”, which is the realization that antioxidant trials have ultimately failed to produce actual results in terms of human diseases associated with oxidative stress.[22-25] Some antioxidants like vitamin C can actually become pro-oxidants at the wrong doses,[26,27] so the time is right for the industry to look elsewhere.
A next-generation immune system support ingredient
Studies have shown that ergothioneine can augment immune system response in macrophages that maintain immune homeostasis, speeding up immune response time.[28]
Prepare to meet NNB Nutrition’s MitoPrime
Due to a range of in vitro and in vivo models where ergothioneine has shown the ability to decrease inflammation, protect against acute respiratory distress syndrome, mitigate damage to the lungs, and far more, the ingredient is suggested as a powerful weapon for fighting novel respiratory diseases and cold viruses.[29]
We can’t produce it, but we have specific transporters for it!
We have a transporter meant for ergothioneine, and it accumulates in our bodies for use when needed! Tissue Expression of the Ergothioneine Transporter, per two different studies.[30,31]
Diving deeper into L-ergothioneine’s research, the information gets even more interesting, with a massive historical evolutionary twist. Mammals (including humans and other vertebrates) cannot synthesize the compound,[32-35] yet we have a unique and specific transporter in our bodies named OCTN1 (formerly ETT) just for this molecule![18,19,30]
The importance of the above paragraph cannot be understated. If this were to be an actual vitamin, we’d consider it an essential one, since we can’t produce it yet can transport and store it with ease.[18,19] And it’s mostly found in foods we rarely eat in Western society.
An evolutionary molecule
Going further back, it gets even wilder. Researchers now believe that ergothioneine predates the oxygenation of Earth’s atmosphere,[15,36-38] providing evidence that it may have even helped organisms survive the planet’s “Great Oxygenation Event” 2.4 billion years ago![39]
While oxygen gives us life, it can also be quite damaging when out of control – oxidative stress and free radical chains are very real threats to our health,[40,41] linked to a plethora of chronic diseases.
Ergothioneine combats numerous types of oxidative stress, including hydrogen peroxide[18,42,43] and singlet oxygen.[21] It also protects against chlorine- and bromine-induced damage,[13,44] various forms of inflammatory stress,[13,45-47] and even nitrogen-based stress.[48,49] With these benefits, we see more genomic stability and can help protect ourselves from devastating damage to our DNA.
Interestingly, it can be synthesized both with and without oxygen.[15,36]
With all of this known, we posit that this lone molecule was a necessary component to our evolution, and life as we know it was built around it. It works wonders but we can’t synthesize it, yet our bodies are ready to transport and store it.
NNB Nutrition’s MitoPrime
Found in mushrooms and organ meats, ergothioneine is the oldest — and most overlooked — antioxidant on the market.
This all makes for the perfect dietary supplement ingredient for general health, and we expect MitoPrime to be the “next big thing” for protective health. It’s a difficult ingredient to manufacture, but NNB Nutrition has figured it out, and is funding new research on it as well. For instance, new data from NNB shows that ergothioneine also has protective antioxidant properties in human red blood cells, indicating both bioavailability and bio-accumulation.[50]
In terms of dosage, the suggestions are to use 5-10 milligrams 2-3 times per day, for a dosage range of 10-30mg/day.
Naturally fermented and sourced L-ergothioneine received generally recognized as safe (GRAS) designation from the FDA in 2018.[51,52] These reports suggests that healthy eaters get roughly 17 milligrams of ergothioneine daily, leading to our supplemental dosing suggestion above. In addition, NNB Nutrition has used its new research and safety data to achieve self-affirmed GRAS status for MitoPrime as well.[53]
Our coffee would shoot for 10 milligrams per strong cup (paired with ~125 – 150 milligrams caffeine) to get the day started right.
The benefits of using MitoPrime branded ergothioneine, as taken from NNB Nutrition’s website
Don’t sleep on this ingredient. We have far more coming, and you can subscribe to PricePlow’s alerts on MitoPrime above or below to learn more when our major article is published.
RhodioPrime 6X (6% Salidroside Rhodiola Extract) – 250mg
With strong research but weak market extracts, NNB Nutrition solved the problem – with the salidroside-rich RhodioPrime 6X — 6% salidroside!
Many health advocates are becoming more aware of Rhodiola, an adaptogenic herb that has long been used for its mood-enhancing and vitality-boosting effects — notably by the Scandinavian Vikings![54,55]
Rosavin and salidroside are the two most bioactive compounds,[56] with research beginning to show that salidroside is the stronger, more experiential driving force.[57]
Rhodiola and salidroside’s mechanisms
With high-salidroside extracts, we see several unique effects:
Rhodiola: The Adaptogen Powered by Salidroside. In this article, we dive deep into rhodiola, and take a different approach to the adaptogenic herb!
- Increased long-term potentiation (LTP) in the hippocampus.[57] LTP is a primary mechanism with respect to learning and memory formation.
- Regulation of mTOR pathway to promote healthy cell proliferation, attenuating damaging cell growth.[58,59]
- Promotion of the oxygenation of blood in the body and brain through HIF-1 (hypoxia inducible factor-1) expression regulation.[60,61]
- Improves the release and uptake of neurotransmitters such as dopamine, serotonin, epinephrine, and norepinephrine.[62-65]
- Functions as a MAO inhibitor,[65] boosting neurotransmitter reuptake.
- Boosts neuropeptide Y activity, which is a signaling agent in the brain related to appetite and satiation.[66,67]
With these effects, we’ve seen incredible benefits with Rhodiola consumption, including the following:
Benefits of Rhodiola
Rhodiola markedly reduced scores of major mood disorders[68]
- Reduced mental fatigue and improved cognition, clarity, and general wellbeing.[69]
- Reduced mental and physical fatigue compared to placebo.[70]
- Stress relief and dramatically improved mood.[68,71-73]
Whether you’re an athlete or simply looking for a bit of a personal pick-me-up, few ingredients feel better than Rhodiola — especially high-salidroside Rhodiola.
It turns out that Rhodiola crenulata has the greatest salidroside content,[54,74] and that’s what NNB Nutrition decided to use in order to create RhodioPrime 6X, their high-salidroside Rhodiola extract. With RhodioPrime 6X, we get at least 6% salidroside, a huge delivery of the energy-, cognition-, and mood-boosting constituent Rhodiola consumers have come to love.
RhodioPrime 6X from NNB Nutrition is a trusted source, and high in salidroside!
There’s far more, so if you want to learn more, read our massive article titled Rhodiola: The Salidroside-Powered Adaptogen of the Vikings.
In terms of our coffee, we stick with a standard 250 milligram dosage of RhodioPrime 6X, but if brands were to create a stack with the Nootropic Coffee Creamer, each one could be adjusted.
CurcuPrime (Tetrahydrocurcumin) – 100mg
Above, we use MitoPrime to get a serious mushroom-based benefit without the taste of mushrooms. Here, we’ll do the same, to get some benefits of curcumin but without the curry-like taste!
Many know that curcumin is the primary bioactive constituent of turmeric, yielding several metabolic health benefits along with improvements to joint inflammation and organ health.[75]
The issue (besides its taste), is that curcumin in its raw form has awful bioavailability![75] This requires massive doses that we can’t reasonably fit into coffee, or spicy ingredients like black pepper to boost absorption. Neither of these work for a functional coffee that’s actually functional!
The future of curcumin is here – and it’s far less pungent and staining!
Using NNB Nutrition’s CurcuPrime (tetrahydrocurcumin), we aim to solve these problems. Tetrahydrocurcumin (4-HC) is a metabolite of turmeric, and is far more efficient in terms of ingestion. It’s also far lower in taste, and is off-white as opposed to orange, so it won’t stain your manufacturer’s equipment.
Research has shown that tetrahydrocurcumin is much more bioavailable than curcumin, and also has stronger antioxidant value.[76] It’s capable of fighting free radicals,[77] but can also help regulate blood sugar levels[78] while also improving some blood lipid levels![79]
Even better, there are cognitive benefits that differ from curcumin:
Acetylcholine protection!
An enzyme named acetylcholinesterase (AChE) deactivates acetylcholine, which we call the “learning neurotransmitter”. In the supplement space, we’re often looking for ways to boost acetylcholine levels and to keep them around longer. A 2014 study showed that tetrahydrocurcumin is able to inhibit AChE almost 2x better than curcumin.[76] This is an angle that competing nootropic and functional coffees are missing.
CurcuPrime: Curcumin’s better half for diet and cardio support
Further, there is some research showing that tetrahydrocurcumin may modulate dopamine levels,[80] combining with RhodioPrime 6X above to add to the feel-good effect of our coffee.
Most take regular curcumin to fight inflammation, and both are equally effective in reducing the interleukins related to inflammation.[81] There are certain targets where tetrahydrocurcumin is better, and others where curcumin is better. In a pill-based supplement, we’d honestly love to use both of them to get the best of both worlds. But in terms of something to drink, there’s only one choice for us, and that’s the more bioavailable, whiter, and curry-less flavor of tetrahydrocurcumin.
To make it happen, NNB Nutrition has a highly-effective, 100% pure and unadulterated form named CurcuPrime. This brings us the potency we seek without the taste or color that we don’t seek.
In terms of dosage for our coffee, we’re shooting for 100 milligrams, which will be a nice boost. For more anti-inflammatory properties, capsules would likely need to be added.
We have far more research in our article titled Tetrahydrocurcumin: A More Potent Alternative to Curcumin?
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